Trial Design Articles

Long-term Electrocardiographic Monitoring: Time to Rethink What We Know?

Feb 22, 2016

By Timothy Callahan, PhD, Joseph Pierro, MD

With significant technology advances in ECG recording through the years, the need to expand on traditional monitoring baselines—and include new variables such as time when designing clinical trial protocols—is important.

Rare Diseases: Meeting the Unique Challenges of Orphan Drug Development

Jan 21, 2016

By Michael F. Murphy, M.D., Ph.D

This article explores the many challenges to creating a pharmaceutical development program for the treatment of a rare disease.

EMA Agrees to Autism Biomarkers

Jan 21, 2016

By Applied Clinical Trials Editors

The EU-AIMS Longitudinal European Autism Project (LEAP) is combining genetic testing, neuroimaging, cognitive testing and clinical assessments to identify biological risk markers associated with subtypes of autism.

Evolution of Value for Oncology Therapies

Sep 08, 2015

By Thomas F. Goss, Nicole Sweeney, Michael F Murphy, MD, PhD

In recent years, the United States has witnessed significant progress in the fight against cancer, with survival rates increasing from 49% in the mid-1970s to 68% today.

Designing Alzheimer’s Disease Clinical Trials For Success

Sep 08, 2015

By Jillian Scaife, Nick Simmons-Stern

Alzheimer’s disease is and will remain one of the most unyielding public health crises of the 21st century.

Trial Design News

ERT Integrates Asthma Measurement Device

ERT announces it has successfully integrated the fractional exhaled Nitric Oxide (FeNO) measurement device by Aerocrine, a Circassia subsidiary, into it’s diagnostic platform for spirometry, ECG and home monitoring for centralized clinical trials.

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