Trial Design Articles

Building Blocks for Better Balance

Sep 28, 2016

By Scott Hamilton, PhD, Carol Shum

While block randomization has been shown to be a more frequently used form of trial randomization design, the use of dynamic randomization has been shown to have optimal treatment group balancing results.

FAQs for Immunotherapy Trials

Sep 12, 2016

By Andrew Zupnick, PhD

Immunotherapy drugs have led to successes in the oncology space as the list of cancer survivors continues to grow. However, more work must be done to ensure that all patients who can benefit from these life-saving drugs receive them.

Future Directions of Cancer Immunotherapy in Clinical Trials

Jun 20, 2016

By Joseph Pierro, MD, Donald Cooper

Progress and innovation within oncology has accelerated to a paradigm that includes immunotherapy and bio-genomics. Collaborative approaches in the future will continue to transform treatments in hopes of improving patient quality of life.

Long-term Electrocardiographic Monitoring: Time to Rethink What We Know?

Feb 22, 2016

By Timothy Callahan, PhD, Joseph Pierro, MD

With significant technology advances in ECG recording through the years, the need to expand on traditional monitoring baselines—and include new variables such as time when designing clinical trial protocols—is important.

Rare Diseases: Meeting the Unique Challenges of Orphan Drug Development

Jan 21, 2016

By Michael F. Murphy, M.D., Ph.D

This article explores the many challenges to creating a pharmaceutical development program for the treatment of a rare disease.

Trial Design News

iCardiac Collaborates with SNBL Clinical Pharmacology Center

iCardiac Technologies and SNBL Clinical Pharmacology Center have announced a collaboration on cardiac safety studies in Japan.

Boehringer Ingelheim and DCRI Expand Collaboration

Boehringer Ingelheim and the Duke Clinical Research Institute (DCRI) announce the expansion of the Idiopathic Pulmonary Fibrosis – PROspective Outcomes (IPF-PRO) Registry.

Quintiles Allies with DaVita Clinical Research

Quintiles and DaVita Clinical Research have allied to provide capabilities and solutions for renal disease clinical trials.

CTTI Recommends New Vaccine Approaches

The Clinical Trials Transformation Initiative (CTTI) have released recommendations for hospital acquired and ventilator-associated bacterial pneumonia (HABP/VABP) as part of its antibacterial drug development program.

eClinicalHealth Announces Results of Remote Online Clinical Trial

eClinicalHealth announced the the final results of the VERKKO remote online Phase IV clinical trial for diabetes.

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