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Simcyp has extended its model repertoire for biologics by incorporating a full physiologically-based pharmacokinetic (PBPK) model for monoclonal antibodies and therapeutic proteins with significant practical applications. In addition, the inclusion of a non-linear plasma protein and red blood cell binding facility in version 13 addresses a level of complexity that is regularly needed for modeling in the oncology arena. The integration of a novel sophisticated IVIVC tool to handle in vitro - in vivo correlations of dissolution for various solid oral dosage forms enhances the scope of the simulator in the divisions of Formulation and Pharmaceutics.
Commenting on the new release, Professor Amin Rostami, vice president of research and development at Simcyp, said: “The expanding scientific expertise and diversity of specialties within Simcyp R&D over the last few years have enabled us to address many different areas that Consortium member companies were interested in. The latest release is a clear manifestation of the breadth and depth of knowledge within the team who fully complement each other.”
Reflecting on the expansion of the model repertoire for generic manufacturers and companies focusing on biologics, Dr Steve Toon, vice president of consulting services and technical sales support at Simcyp, commented: “Simcyp continues to enhance and evolve its products and services in line with the changing face of the pharmaceutical industry. With many of our Consortium member companies’ growing interest in biologics and increasing requests for consultancy support from the biotech and generics communities, the enhanced features within version 13 keep Simcyp at the forefront of PBPK modeling and simulation research, science, products and consultancy services.”
Version 13 of the Simcyp Simulator is now available to all Consortium members and academic associates with current not-for-profit license agreements.