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US Oncology Research, one of the nation’s largest research networks specializing in Phase I through IV oncology clinical trials, announced today it is collaborating with BioMarin Pharmaceutical Inc. to offer a groundbreaking Phase III study to investigate the use of BMN 673, a PARP inhibitor, in metastatic breast cancer patients who test positive for BRCA1 or BRCA2 gene mutations. The study will investigate the effectiveness and safety of BMN 673, adding to the promising data currently being analyzed from ongoing Phase I and II studies of the drug. Thirteen US Oncology Research affiliated practices with 56 locations will participate in the study.
“We are excited to collaborate with BioMarin on this important study that can lend more insight into the potential of PARP inhibitor BMN 673 in a metastatic breast cancer setting,” said Joanne L. Blum, M.D., medical oncologist and director, Hereditary Cancer Risk Program, Texas Oncology-Baylor Charles A. Sammons Cancer Center and a principle investigator for the study. “This is an opportunity for patients who have a BRCA1 or BRCA2 gene mutation with metastatic breast cancer to receive an investigational PARP inhibitor to see if it will help control the metastatic disease compared to standard chemotherapy. Eligible patients have the possibility of receiving a promising novel therapy not available elsewhere while participating in a world-class study that may change patients’ lives in the future,” she noted.