# Applied Clinical Trials Online

> Applied Clinical Trials Online - Healthcare Publication

- Base URL: https://www.appliedclinicaltrialsonline.com
- Generated: 2026-10-21T00:23:01.971Z
- Content updates: multiple times daily

## Content Access for AI Agents

This site supports content negotiation for AI/LLM consumption. Request any article URL with an appropriate Accept header to receive structured content instead of HTML.

**Supported content types:**
- `text/markdown` — Clean Markdown with YAML frontmatter
- `text/plain` — Plain text (same as Markdown)
- `text/html` — Default HTML response

**Example request:**
```
curl -H "Accept: text/markdown" https://www.appliedclinicaltrialsonline.com/view/article-slug
```

**YAML frontmatter schema** (returned with every Markdown response):

| Field | Type | Description |
|-------|------|-------------|
| `title` | string | Article headline |
| `description` | string | Summary/excerpt (max 300 chars) |
| `url` | string | Canonical article URL |
| `canonical_url` | string | Canonical URL if different from `url` |
| `published` | ISO 8601 | Original publication date |
| `modified` | ISO 8601 | Last modification date |
| `authors` | string[] | Author display names |
| `content_type` | string | Content category (e.g., "News", "Clinical") |
| `categories` | string[] | Taxonomy categories |
| `tags` | string[] | SEO tags |
| `image` | string | Featured image URL |
| `publisher` | string | Publication/site name |

**Discovery headers** (included on all responses):
- `Link: <https://www.appliedclinicaltrialsonline.com/llms.txt>; rel="llms"` — RFC 8288 link to this file
- `X-Llms-Txt: https://www.appliedclinicaltrialsonline.com/llms.txt` — Explicit discovery header

## Usage Policy

- Robots policy: [https://www.appliedclinicaltrialsonline.com/robots.txt](https://www.appliedclinicaltrialsonline.com/robots.txt)
- Cache behavior: responses are cached for ~5 minutes (max-age=300, stale-while-revalidate=329)
- Rate guidance: prefer RSS and sitemap feeds over crawling individual pages
- Attribution: All content © MJH Life Sciences. Include source URLs when citing.

## Content Categories

- [Additional Topics](https://www.appliedclinicaltrialsonline.com/additional-topics)
- [Blogs](https://www.appliedclinicaltrialsonline.com/blogs)
- [Editorial Podcasts](https://www.appliedclinicaltrialsonline.com/editorial-podcasts)
- [Editorial Videos](https://www.appliedclinicaltrialsonline.com/editorial-videos)
- [Events](https://www.appliedclinicaltrialsonline.com/events)
- [Front & Center](https://www.appliedclinicaltrialsonline.com/front-center)
- [NO ADS](https://www.appliedclinicaltrialsonline.com/noads)
- [News](https://www.appliedclinicaltrialsonline.com/news)
- [Sponsored Podcasts](https://www.appliedclinicaltrialsonline.com/podcasts)
- [Sponsored Videos](https://www.appliedclinicaltrialsonline.com/sponsored-videos)
- [Topic](https://www.appliedclinicaltrialsonline.com/topic)
- [Vendor Strategy & Collaboration](https://www.appliedclinicaltrialsonline.com//topic/vendor-strategy-and-collaboration)
- [Video Series](https://www.appliedclinicaltrialsonline.com/video-series)
- [Webcasts](https://www.appliedclinicaltrialsonline.com/webcasts)
- [White Papers](https://www.appliedclinicaltrialsonline.com/whitepapers)

## Featured Content

- [Syneos Health, Optum Partner on Adaptive Clinical Development Model](https://www.appliedclinicaltrialsonline.com/view/syneos-health-optum-adaptive-clinical-development-model-partnership): Syneos Health and Optum outline a joint model for trial planning, recruitment and site access, with no financial terms or timelines disclosed.
- [AstraZeneca and Oracle Outline AI Collaboration for Clinical Trial Recruitment and Safety Monitoring](https://www.appliedclinicaltrialsonline.com/view/astrazeneca-oracle-ai-collaboration-clinical-trial-recruitment-safety-monitoring): What sponsors and sites should know about the AstraZeneca-Oracle AI collaboration on trial recruitment, safety monitoring and data governance.
- [Where AI Governance in Clinical Development Falls Short](https://www.appliedclinicaltrialsonline.com/view/where-ai-governance-clinical-development-falls-short): In this video interview, Rajneesh Patil, global head of AI, digital, and innovation in clinical development at Syneos Health, identifies three recurri...
- [2026 SCRS Global Site Solutions Summit: What's the Biggest Mistake Sites or Sponsors Make When Implementing Advanced Al?](https://www.appliedclinicaltrialsonline.com/view/2026-scrs-biggest-mistake-sites-sponsors-implementing-advanced-al-): CRIO’s chief innovation officer, Mike Wenger touches on the two ways sites get AI adoption wrong.
- [2026 SCRS Global Site Solutions Summit: What Does Al Implementation Look Like Once it Moves Past the Pilot Stage?](https://www.appliedclinicaltrialsonline.com/view/2026-scrs-al-implementation-look--past-pilot-stage-): CRIO’s Mike Wenger, speaker at this year's SCRS summit, maps how sites are actually deploying AI post-pilot stage.
- [How Compressing Time From Data Capture to Insight Changes Trial Risk Management](https://www.appliedclinicaltrialsonline.com/view/compressing-time-data-capture-insight-changes-trial-risk-management): In this video interview, Rajneesh Patil, global head of AI, digital, and innovation in clinical development at Syneos Health, explains why the real ad...
- [ACT Brief: AI Operating Models, Oncology Evidence Trust, and Thyroid Eye Disease Approval](https://www.appliedclinicaltrialsonline.com/view/ai-operating-models-oncology-evidence-trust-thyroid-eye-disease-approval): In today’s ACT Brief, we examine how AI is moving into continuous clinical operating models, how trust is built into oncology real-world evidence, and...
- [2026 SCRS Global Site Solutions Summit: Should the Industry Rethink What Scale Means?](https://www.appliedclinicaltrialsonline.com/view/2026-scrs-should-industry-rethink-scale-means-): Paradigm’s Kurt Mussina discusses why scale should drive operational efficiency, not consolidation into single-site studies. 
- [2026 SCRS Global Site Solutions Summit: The Difference Between Owning a Group of Sites and Operating Them as One Integrated Platform](https://www.appliedclinicaltrialsonline.com/view/2026-scrs-difference-between-owning-group-sites-operating--one-integrated-platform): Paradigm’s Kurt Mussina touches on why he rejects the “site management organization” model in favor of one unified business. 
- [2026 SCRS Global Site Solutions Summit: What's a Mistake Sponsors or CROs Make When Rolling Out New Trial Technology?](https://www.appliedclinicaltrialsonline.com/view/2026-scrs--mistake-sponsors-cros-rolling-new-trial-technology-): ProofPilot’s Lauren Briggs talks on why sponsors and CROs fail at tech rollouts by skipping change management, and pushes for the industry to judge tr...

## Feeds and Indexes

- [RSS Feed](https://www.appliedclinicaltrialsonline.com/rss.xml): Latest articles in XML syndication format
- [Sitemap](https://www.appliedclinicaltrialsonline.com/sitemap.xml): Complete URL index for all published pages
- [News Sitemap](https://www.appliedclinicaltrialsonline.com/sitemap-news.xml): Recent articles optimized for news indexing
- [Authors Directory](https://www.appliedclinicaltrialsonline.com/authors): Browse all contributors and their published work