IMS data show the importance of the role clinical investigators play in prescribing.
IMS data show the importance of the role clinical investigators play in prescribing.
Clinical investigators play two important roles in the new drug process. They are integral parts of the creation of medical innovation. As researchers, these physicians participate in the clinical trials that generate the medical data used by regulatory authorities to evaluate the efficacy and safety of compounds, which may become marketed drugs. Clinical investigators are also important in the adoption of medical innovation. IMS prescribing data show that clinical investigators who have participated in the clinical trial of a new compound were more likely to prescribe that drug when, and if, it came to market than were a matched set of physicians who had never acted as clinical trial investigators.
The difference in prescribing levels is immediate and sustained over the 18 months from the date of the first recorded filled prescription that the analysis covered. Interestingly, the more innovative the drug, the greater the difference between the investigators and the control physicians.
Few clinical investigators are world famous medical authorities. Most are practicing physicians, seeing patients on a regular basis. These investigators act as a type of local opinion leader, influencing the other physicians with whom the investigators come into contract. Extensive research has demonstrated that the number one factor influencing a physician’s decision to prescribe a new drug for the first time is the opinion of another respected physician. Many clinical investigators may play this role of a respected physician and may be viewed by other doctors as important medical information resources about the newly marketed drug.
Average Market Share for New Drug
3, 6 and 18 Months After Market Launch
Source: Department of Health Policy and Public Policy, University of the Sciences, Philadelphia, PA, using IMS Health data.
Putting Collective Insights Into Action to Advance Cancer Care: Key Examples From ASCO 2025
June 27th 2025At ASCO 2025, clinical operations leaders gained critical insights into how AI tools, bispecific antibodies, and evolving treatment paradigms are reshaping trial design, endpoint selection, and patient stratification.
Unifying Industry to Better Understand GCP Guidance
May 7th 2025In this episode of the Applied Clinical Trials Podcast, David Nickerson, head of clinical quality management at EMD Serono; and Arlene Lee, director of product management, data quality & risk management solutions at Medidata, discuss the newest ICH E6(R3) GCP guidelines as well as how TransCelerate and ACRO have partnered to help stakeholders better acclimate to these guidelines.
Funding Cuts Threaten Diversity in Clinical Research
June 27th 2025In this video interview, Kyle McAllister, co-founder, CEO, Trially, discusses how recent federal funding cuts are likely to undermine research focused on underrepresented populations, and why long-term investment in community-based studies is essential to closing persistent health equity gaps.