In this video interview, C.K. Wang, MD, chief medical officer, COTA, discusses a recent study he led on the validity of using real-world data for reporting mortality.
In a recent video interview with Applied Clinical Trials, C.K. Wang, MD, chief medical officer, COTA, discussed a recent study he led on leveraging real-world data (RWD) to improve oncology reporting. Additionally, Wang highlighted recent trends and challenges in the oncology research space involving the use of RWD as well as real-world evidence (RWE).
ACT: Could you give our audience an overview of the recent study you led on leveraging RWD to improve reporting in oncology?
Wang: To start, COTA is an oncology real-world data company, and our data is clinical and comes from the actual medical record systems for our provider partners, and over the past six years, we have built large, ready to use databases across both blood cancers and solid tumors. I will say that two foundational components to when one is looking to use any real-world data set is to understand, number one, whether or not it is actually accurate, whether that you know that the data that you see is actually accurate, but more importantly is to understand how complete that data is. As we all know, in clinical trials, especially in oncology, overall survival remains the gold standard by which any new therapy is actually being looked at. The completeness of the mortality data, whether it be in the clinical trials or in real-world data, remains extremely important. This is exactly what we set out to do in our study. We looked at, across all of our hematologic cancer databases, and we compare the accuracy and the completeness of our composite mortality variable against the national death index, which is the gold standard death database as we know it today.
Stay current in clinical research with Applied Clinical Trials, providing expert insights, regulatory updates, and practical strategies for successful clinical trial design and execution.
Unifying Industry to Better Understand GCP Guidance
May 7th 2025In this episode of the Applied Clinical Trials Podcast, David Nickerson, head of clinical quality management at EMD Serono; and Arlene Lee, director of product management, data quality & risk management solutions at Medidata, discuss the newest ICH E6(R3) GCP guidelines as well as how TransCelerate and ACRO have partnered to help stakeholders better acclimate to these guidelines.
Reblozyl Misses Primary Endpoint in Phase III Myelofibrosis Trial but Shows Clinical Promise
July 21st 2025The Phase III INDEPENDENCE trial (NCT04717414) failed to meet its primary endpoint of achieving transfusion independence in patients with myelofibrosis-associated anemia treated with Reblozyl (luspatercept-aamt).
Managing Side Effects and Dosing in Off-Label GLP-1 Use with Help from Real-World Evidence
July 18th 2025Shipra Patel, global therapeutic area section head, endocrinology, global head, pediatrics, Parexel, explains how real-world data is helping researchers navigate gastrointestinal side effects, dose flexibility, and long-term tolerability in off-label GLP-1 use.