 was first formed during a meeting, held by the EFPIA in Brussels, in 1990. Representatives of the regulatory agencies and industry associations of Europe, Japan, and the United States met, primarily, to plan an International Conference. 

1991– The adoption of final version of " common rule" governing protection of human subjects for research sponsored by all federal agencies  

1993 – Second ICH Conference in Orlando. 

1996 – Third ICH Conference in Yokohama.

 (Health Insurance Portabiality & Accountability Act) with provisions regarding privacy of human medical records. 

1997– FDAMA-pediatric studies & incentives (expanded under 2003 Pediatric Research Equity Act); 