Scott Hamilton, PhD


An Adaptive-Block Randomization Method when Stratifying by Investigator in Small-to Medium-Sized Studies

October 26, 2020

A novel adaptive-block method of randomization to maximize the efficiency of overall treatment group balance, while maintaining balance at investigational centers in smaller sized studies, is proposed.

Building Blocks for Better Balance

September 28, 2016

While block randomization has been shown to be a more frequently used form of trial randomization design, the use of dynamic randomization has been shown to have optimal treatment group balancing results.

A Comparison of Techniques for Creating Permuted Blocked Randomization Lists

February 12, 2016

Two of the most important elements to the integrity of a controlled clinical trial are the patient randomization and the treatment blinding. With a focus on block pattern distribution, four methods of randomization list creation are analyzed.