The current oncology drug development market.
The global market in sales for oncology drugs is anticipated to expand from around $48 billion in 2008 to more than $85 billion in 2013. This is based on 2008 data from Cutting Edge Information. Currently, more than 4,700 clinical trials are in progress for oncology drugs.
Medicines in Development For Cancer
John W. Hubbard, PhD, FCP, Global President, ICON Clinical Research, had shared in an interview conducted in 2009 that ICON was seeing increased activity in the oncology space and had in fact added three more oncologists to its corporate staff in the United States. Exploring the reasons behind the increase, as well as the apparent, but not wholesale, migration of oncology trials from academia to mainstream trial venues, Hubbard noted the toxicity shift in medicines available for cancer treatment. "The older drugs were very toxic with side effects that needed to be managed," said Hubbard. "With the newer drugs, they are more targeted and the side effects aren't as bad. And there are more of them, so they are moving into a traditional drug development model."
In fact, in a recent survey from US Oncology, 53% of the respondents felt that recruiting patients to clinical trials for targeted therapies will be less difficult than large-scale randomized trials of more traditional cytotoxic therapies. The survey respondents included a mix of oncologists (67%), and the balance clinical research professionals (33%).
The US Oncology respondents believed that subject recruitment for clinical trials is most successful at academic medical centers (AMCs), and the reasons given in order were: better patient acceptance, large patient population/database, and more staff.
Meanwhile, getting trials up and running remains a two-fold problem, one that AMCs may need to heed. The US Oncology survey found that regulatory red tape was the primary cause that slowed down a trial's approval. Couple that with another study from KMR Group on site contracting practices, which found site contract approval time is five to six weeks on average, but double for an oncology trial, with problems specific to start up. KMR Group attributes the lengthened oncology time to both a greater tendency for those studies to be conducted at institutional sites, which tend to take longer, and the greater complexity of oncology protocols, e.g., due to patient issues.
Including Women of Childbearing Age in Clinical Research
March 26th 2024In recognition of International Women's Month, we're featuring this recent talk between Associate Editor Miranda Schmalfuhs and Marie Teil, Global Head of UCB’s Women of Childbearing Age Program. They speak about the specific challenges women with chronic illnesses face when accessing appropriate treatment and participating in clinical trials, UCB's Women of Childbearing Age Program and it’s most successful strategies, and much more.
Improving Engagement While Maintaining Data Integrity & Validity
March 19th 2024In recognition of Women's Health Month, we're featuring this recent talk between Associate Editor Miranda Schmalfuhs and uMotif's Chief Product Officer, Julia Lakeland, discuss new technologies improving patient engagement and reducing the emotional and logistical burdens of participation, ethical considerations that should be addressed when implementing those technologies, while ensuring patient privacy, and much more.