News|Articles|October 6, 2017

Vaccine-Induced Specific Immune Response Offers an Avenue to Potentiate Responses to Immune Checkpoint Inhibitor Therapy

Cancer vaccine-based immunotherapy may help overcome the resistance of certain tumors to immune checkpoint inhibitors, while immune checkpoint inhibitors may enhance the efficacy of cancer vaccine therapies.

Cancer was once considered a disease of genetic origin, with hallmarks including sustained proliferation, resistance to apoptosis, the ability to promote angiogenesis, and the ability to promote invasion and metastasis. However, this view failed to take into consideration the dynamic nature of the interactions between a tumor and its microenvironment-not just the normal cells in the surrounding tissue, but also the immune system.

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