Applied Adaptive Design Using Subgroup Identification & Machine Learning

A case study example of study design using the latest tools and methodologies. Learn how you can complete your study potentially quicker and with fewer subjects while increasing probability of trial success.

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Event Overview:

• Applied case study example of study design using the latest tools and methodologies
  • Phase-3 oncology design as a case study
  • Latest AI/ML tools to leverage Phase-2 study data to set patient inclusion/exclusion criterion for broadest possible label as well as increase probability of study success. This also potentially reduces cost and time to run trial
  • Use of latest adaptive trial design innovations to reduce trial cost, risk, and time
  • Adaptive accrual to incorporate actual response and hazard rates for efficient trial execution without sacrificing power
  • Case study wrap-up from clinician’s perspective with all these efficiencies and optimizations

Three Key Take-aways:

• What good looks like for trial design
• How newer methods can reduce the cost of running a trial
• Evaluate how trials can be run quicker using new methods

Speakers

Kal Chaudhuri
Principal, AI/ML Applications & IQVIA Trial Designer

Kal currently leads SOMS & ITD products for IQVIA. His experience is in Artificial Intelligence & Machine Learning (AIML) and new product development and global launch. His specialty is in integrating clinical trial and real-world data sources to discover insights using AIML platforms & algorithms. These methodologies can be used for disease detection and personalized treatment.

Kal brings over 25 years of experience leading technology and business. Kal has worked extensively across technology enabled solutions, services, product life cycle management from organizational & process design, marketing & product management in healthcare and technology services through strategic partnership management & regulatory approval. Kal’s experience prior to IQVIA include leading portfolio transformation for Ricoh, leading health imaging & cancer detection products at Siemens and a variety of other roles.

Eric Groves
VP Strategic Drug Development Design and Delivery innovation
IQVIA

Dr. Groves is Board Certified, in oncology and internal medicine with 32+ years of experience in drug development as corporate officer/senior manager, clinician and researcher. Noteworthy are his accomplishments in clinical and preclinical development, research and general management, for agents with oncologic, infectious disease, immunologic, dermatologic and pain therapy applications. At IQVIA, Dr Groves has provided drug development guidance to a wide variety of clients both small biotech and large pharma. Dr. Groves received his B.S. degree from Massachusetts Institute of Technology and his Ph.D. in physics from the University of Pennsylvania. He earned his M.D. at the University of Miami and completed an internal medicine residency followed by a National Cancer Institute oncology fellowship.

Eva Miller
Director, Biostatistics / CSDD, IQVIA Decision Sciences
IQVIA

Eva currently serves as a thought leader and consultant in statistical methodology for clinical trial design, provide strategic guidance to clients. She specializes in innovative, complex trial designs, adaptive designs, and development of master protocols. She also serves as a member of data monitoring committees, either as blinded or unblinded statistician and support sponsors through the statistical process in interacting with regulatory authorities.

Eva has over 30 years’ experience as statistical science expert in healthcare, pharmaceutical, biotech and start-up industries, non-profit organizations, and academia. Prior to joining IQVIA in January 2022, held leadership positions of increasing responsibility at Cytel, PRA, Syneos, ICON, and ALMAC and consulting roles at Merck, Pfizer, Bristol Myers Squibb, and several biotechs. Before I served as biostatistician /epidemiologist in the NJ Health Dept and psychometrician at the NJ Education Dept. Eva has also authored/co-authored over 100 publications in peer-reviewed journals, presented on innovative & adaptive designs, various statistical methods at conferences in US, Europe.

Register Free: https://globalmeet.webcasts.com/starthere.jsp?ei=1568893&tp_key=ed851ed0c6