Commentary|Videos|October 14, 2025

Enhancing Data Quality and Real-World Evidence in Clinical Research

Uncover how improving data accuracy and leveraging synthetic control arms can optimize trial efficiency, reduce costs, and generate stronger real-world insights.

In this video interview clip, Cameron Breze, product manager, Inovalon, and Sujay Jadhav, CEO of Verana Health, discuss the importance of high-quality data and the role of real-world evidence and synthetic control arms in clinical research. They emphasize how inaccurate or incomplete data can compromise machine learning models and study outcomes. The conversation also explores how leveraging large, longitudinal real-world datasets can enhance efficiency and reduce the cost of traditional patient recruitment.

Breze: Quality data is something that is top of mind for everyone in the in the data technology space. Many people like to use the age-old adage of garbage in garbage out when it comes to machine learning models and a lot of the data modeling that's available where if you're feeding it with inaccurate information, you're going to get a result that really can't be transposed and moved and translated into anything that's really applicable and that ends up being a waste of institutional resources and not the best way to serve patients.

Jadhav: Historically, recruiting patients where you're not providing them the treatment, as you can imagine, is very, very expensive and very time consuming overall. I think that's the area where you look at synthetic control arms, and leveraging real-world data can help be a good proxy, or can help augment and allow you to compare and contrast to the treatment arm. The good thing with real-world data and leveraging it for these type of control arms is that the volume is very, very large, and the quality and the longitudinality of the data is pretty good as well.


Related to this article

Where the Industry Is Headed as Clinical, Operational, and Real-World Data Connect
In this video interview, Rajneesh Patil, global head of AI, digital, and innovation in clinical development at Syneos Health, describes the industry’s trajectory toward a unified intelligence orchestration environment—and explains why the future isn’t one model that knows everything, but a trusted system that brings the right evidence to the right human decision.
© photon_photo - © photon_photo - stock.adobe.com
Standardized measurement across five oncology centers found that clinical research coordinators rated eSource-enabled workflows positively (Overall Mean Satisfaction 5.79 of 7), with reduced manual entry and electronic data transfer earning strong marks, while perceived reduction in sponsor and monitor queries lagged as the one domain below threshold.
What Expanding AI Ecosystems Mean for Sponsor Complexity and Oversight
In this video interview, Rajneesh Patil, global head of AI, digital, and innovation in clinical development at Syneos Health, argues that CROs must act as orchestrators rather than aggregators—and that the real test of any AI ecosystem is whether it reduces sponsor coordination burden or just hands it back to them.
Where AI Governance in Clinical Development Falls Short
In this video interview, Rajneesh Patil, global head of AI, digital, and innovation in clinical development at Syneos Health, identifies three recurring failure modes in AI governance frameworks—and explains why responsible AI must be an ongoing operating discipline, not a one-time approval gate.