Jeffrey L Probstfield, MD

How one large academic trial adopted a coordinating center model-helping drive early-model RBM gains

The largest antihypertensive trial ever conducted throughout North America, ALLHAT, was organized using a coordinating center model for oversight. Regional coordinators played a key role in carrying this trial out.

Using a specific trial, the importance of assessing the success of therapy masking is examined.

An important criterion for a well-conducted clinical trial is minimization of bias in endpoint assessment.