Applied Clinical Trials-10-01-2025

View the Applied Clinical Trials October 2025 issue in an interactive format.

A redesigned look and inaugural State of the Industry survey highlight Applied Clinical Trials' October issue.

Advancing toward more meaningful use of PRO data by making it systematic, transparent, and built into trial design.

The quest to turn patient retention from a chronic challenge into a competitive strength—and one that benefits all stakeholders.

With global supply chains inherently vulnerable to trade policy shifts, the consequences for clinical research can be significant without proactive planning. The eight core elements of a tariff contingency plan are outlined.

How a strategic approach to the pre-investigational and investigational new drug application process can be used as a business and clinical catalyst.

Sustainability should be central to clinical trial design and considerate of how digital tools such as electronic clinical outcomes assessments can help achieve this.

Although DEI remains a core tenet in pharma, strategies and goals have been reframed to align with the evolving political climate.

To maximize the impact of signal detection, KRI frameworks should follow a few guiding principles.

Capturing insights from clinical research professionals on the key trends and challenges shaping drug development today, from those in clinical trial operations and site relationships, to technology and AI, and the evolving regulatory and policy terrain.

An analysis of primary Phase II protocols paired with their Phase III pivotal trials spotlights the need to balance scientific curiosity with participant and site burden.

Why discussions with patients should go deeper than data-centered dialogues—and emphasize trust, personal connections, and community engagement to foster informed choices in public health.

Ways to identify false certainty, or "errogance," during the clinical site start-up-to-launch process—and better ensure site readiness and prevention of costly errors.

New guidance and technology advances are reshaping eClinical systems, positioning them as tools to accelerate enrollment, improve data quality, and reduce site and patient burden.